Hyperbaric oxygen therapy for Alzheimer's dementia with positron emission tomography imaging: a case report
Harch, Paul G. MD1,*; Fogarty, Edward F.2
Medical Gas Research 8(4):p 181-184, Oct–Dec 2018. | DOI: 10.4103/2045-9912.248271
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Abstract
A 58-year-old female was diagnosed with Alzheimer’s dementia (AD) which was rapidly progressive in the 8 months prior to initiation of hyperbaric oxygen therapy (HBOT). 18Fluorodeoxyglucose (18FDG) positron emission tomography (PET) brain imaging demonstrated global and typical metabolic deficits in AD (posterior temporal-parietal watershed and cingulate areas). An 8-week course of HBOT reversed the patient’s symptomatic decline. Repeat PET imaging demonstrated a corresponding 6.5–38% regional and global increase in brain metabolism, including increased metabolism in the typical AD diagnostic areas of the brain. Continued HBOT in conjunction with standard pharmacotherapy maintained the patient’s symptomatic level of function over an ensuing 22 months. This is the first reported case of simultaneous HBOT-induced symptomatic and 18FDG PET documented improvement of brain metabolism in AD and suggests an effect on global pathology in AD.
INTRODUCTION
The prevalence1,2 and costs2 of dementia, of which Alzheimer’s dementia (AD)3 is the dominant subtype, are substantial.3 AD is characterized by deficits in memory and executive function.4 Treatments have focused on pharmacotherapy,5 but from 2002–2012 the US Food and Drug Administration has cleared only 1 of 244 drugs tested6 and no therapy halts disease progression.7
The dual-drug hyperbaric oxygen therapy (HBOT)8,9 has many neurological applications.10 The first successful HBOT-treated case of AD was published in 2001.11,12 The present case report is the first patient in a series of 11 HBOT-treated AD patients whose symptomatic improvement is documented with 18fluorodeoxyglucose positron emission tomography (18FDG PET).
CASE HISTORY
The patient is a 58-year-old, Caucasian female with 5 years of cognitive decline that accelerated 8 months pre-HBOT. Seven months pre-HBOT extensive metabolic, vitamin deficiency, serologic, rheumatologic, imaging, cardiac, and medical evaluations, including apolipoprotein E (APOE) allele testing (homozygous e3) were negative. Electroencephalogram showed diffuse slowing; neuropsychological testing demonstrated multiple cognitive deficits. Single photon emission computed tomography (SPECT) was abnormal, suggesting AD (Figure 1). 18FDG PET imaging 6 months post-SPECT and 1 month pre-HBOT confirmed AD (Additional video 1). Medical history: natural gas inhalation-induced syncope at 8–10 years old (subsequent referral for Special Education), decades’ exposure to metallurgy factory and oil refineries, chronic hypotension, and ten-year work exposure to mold pre-diagnosis. No substance abuse or family history of AD. Brother with dementia secondary to multiple concussions, substance abuse, electroconvulsive therapy. Physical exam: confusion following commands, slight tremor, decreased pinprick diffusely, bradykinesia, hyperreflexia, dysdiadochokinesia, finger-to-nose incoordination, and instability on deep knee bend, tandem gait, and Romberg. Patient refused medications except Lexapro and vitamins.
Figure 1:
Single photon emission computed tomography brain blood flow imaging 7 months pre-hyperbaric oxygen therapy (selected transverse slices). Note significant regional reduction in flow to left posterior temporalparietal region (white arrows).
The patient received forty 1.15 atmosphere absolute/50 minutes total treatment time, once per day, 5 days per week, HBOTs in 66 days. After 21 HBOTs the patient reported increased energy/activity level, mood, and ability to draw a correct clock face, perform activities of daily living, and work crossword puzzles. Rivastigmine patch was started and discontinued after one week due to ineffectiveness (patient report). At completion of 40 HBOTs patient reported increased memory and concentration, sleep, conversation, appetite, ability to use the computer, more good days (5/7) than bad days, resolved anxiety, and decreased disorientation and frustration. Tremor, deep knee bend, tandem gain, and motor speed were improved. Repeat 18FDG PET imaging one month post HBOT showed global 6.5–38% improvement in brain metabolism (Additional Videos 2-6; Additional Tables 1–3).
Additional Table 1 - 18Fluorodeoxyglucose positron emission tomography transverse slice cortical ribbon and posterior temporal-parietal watershed regions of interest (caudal to cephalad) pre/post-hyperbaric oxygen therapy
CorticalRibbonPosteriorWatershRightPosteriorWatershLeft
SlicePrePost% ΔPrePost% ΔPrePost% Δ38/6852065926.743151018.332939620.43951565326.839146518.935243523.64050763525.236444422.033941321.84150662924.335544725.934440918.94249964028.336644321.033438314.74351264225.438343814.431736314.54451965726.638943411.632035912.24552864221.639844612.13163386.964650862022.03884228.763213426.54
Average51364225.238545017.033038215.5
Note: Pre/post: pre/post-hyperbaric oxygen therapy. % Δ: (Post - Pre)/Pre × 100%.
Additional Table 2 - 18Fluorodeoxyglucose positron emission tomography coronal slice bilateral cingulate cortices regions of interest (anterior to posterior) pre/post-hyperbaric oxygen therapy
Slice numberPrePostChange% Change4047560913428.24151164413326.04246862415633.34345162417338.34447865818037.74548666217636.24651665914327.74749260811623.6485176028516.4495466237714.1
Average49463113728.1
Note: Pre/post: pre/post-hyperbaric oxygen therapy. Change = Post - Pre. % Change = Change/Pre × 100%.
Additional Table 3 - 18Fluorodeoxyglucose positron emission tomography sagittal slice of bilateral cingulate cortex and ROI (right to left) pre/post hyperbaric oxygen therapy
Slice #PrePostChange% Change60/12843055312328.66145456911525.36249560611122.4634805547415.4644915485711.6654765275110.7
Average4715598919.0
Note: ROI: Regions of interest; pre/post: pre/post-hyperbaric oxygen therapy. Change = Post - Pre. %Change = Change/Pre × 100%.
Texture analysis demonstrated a global decrease in the coefficient of variation (CV) except in the Alzheimer’s typical ROIs (Additional Tables 4 and 5). Two months post-HBOT the patient felt a recurrence in her symptoms. She was retreated over the next 20 months with 56 HBOTs (total 96) at the same dose, supplemental oxygen, and medications with stability of her symptoms and Folstein Mini-Mental Status exam (Additional Table 6).
Additional Table 4 - Coefficient of variation in 18fluorodeoxyglucose positron emission tomography transverse slice of cortical ribbon and temporal-parietal watershed regions of interest (right to left) pre/post HBOT
Pre-HBOTPost-HBOT
Slice #Right post watershedLeft post watershedCortical ribbonRight post watershedLeft post watershedCortical ribbon38/6820.140.426.721.441.920.33921.728.726.823.431.320.44023.332.227.826.832.222.04121.126.626.920.126.221.94220.528.127.725.529.821.74318.827.424.226.033.323.84422.425.622.927.633.422.84522.429.121.825.339.022.74628.129.927.434.438.626.5
Average/change22.029.825.825.6/+3.634.0/+4.222.5/-3.3
Note: HBOT: Hyperbaric oxygen therapy.
Additional Table 5 - Coefficient of variation in 18fluorodeoxyglucose positron emission tomography coronal slice of cingulate cortices (anterior to posterior) pre/post HBOT
Slice #Pre-HBOTPost-HBOTChange40/8126.521.0-5.54120.316.9-3.44222.418.4-4.04327.120.5-6.64422.814.7-8.14525.715.9-9.84621.016.6-4.44722.419.9-2.54820.520.6+0.14920.920.2-0.7
Average23.018.5-4.5
Note: HBOT: Hyperbaric oxygen therapy. Change = Post-HBOT - Pre-HBOT.
Additional Table 6 - Post-40 HBOTs (after August 2016) clinic course with Folstein Mini-Mental Status Scores
Months post 40th HBOTNumber of HBOTsFolstein Mini Mental StatusNotes54022Begins oxygen concentrator two weeks before this date at 2 L/min x 20 minutes (2-5 sessions), 3 times/week and restarts Rivastigmine patch for 4 weeks, 4 weeks post this date97023127023Restart Rivastigmine188819Discontinue Rivastigmine, start Donepezil, 5 mg/d229622
Note: HBOT: Hyperbaric oxygen therapy.
DISCUSSION
AD is a debilitating, costly, rapidly increasing neurological disorder for which there is no effective treatment.1,2,3 Etiology is multifactorial, systemic, and immune health-related from insults that occur across the spectrum of life,13 resulting in reductions of brain regional metabolism.14 Causes include infection,13 diabetes mellitus,13 metabolic disorders,7 and vascular factors.15,16 Four pathological processes have been identified17: vascular hypoperfusion of the brain (and disturbed microcirculation)18 with associated mitochondrial dysfunction,6 2) destructive protein inclusions (intracellular neurofibrillary tangles--phosphorylated and aggregated tau protein), and extracellular amyloid plaques,7 3) uncontrolled oxidative stress, and 4) proinflammatory immune processes13,19 secondary to microglial and astrocytic dysfunction in the brain. While the vast majority of cases are sporadic, genetic predisposition20 and epigenetic changes have been implicated.21 Diagnosis is clinical and can be confirmed with 18FDG PET hypometabolism in established disease,22 but is less reliable in mild cognitive impairment.22,23,24 Primary treatment is with acetylcholinesterase inhibitors or the N-methyl-D-aspartate receptor antagonist memantine5 which have been shown to have positive impact on AD progression25 with no significant disease-modifying effects.26
HBOT is an epigenetic12 modulation of gene expression and suppression8,9 to treat wounds9 and disease pathophysiology,27,28 particularly inflammation.29 HBOT targets all four of the pathological processes of AD by: 1) affecting the microcirculation28,30,31,32,33,34 mitochondrial dysfunction35,36 and biogenesis,37,38 2) reducing amyloid burden and tau phosphorylation,393) controlling oxidative stress,40 and 4) reducing inflammation.29,39,41,42,43
AD was suggested by SPECT and confirmed after rapid clinical decline by 18FDG PET hypometabolism in the typical temporal-parietal and posterior cingulate areas.14,22,24 Forty HBOTs improved symptoms and resting global brain metabolism (6.5–38%), including the watershed and posterior cingulate areas. The largest increases were seen in the anterior and mid-cingulate cortices and the least in the posterior cingulate and watershed areas. To our investigation these results are the largest reported global and regional improvements in resting brain metabolism in AD. Test/retest in normal has shown 0.48–9.85% increases in metabolism over 7–23 weeks,44 25 weeks,45 and 17 days,46 while acetylcholinesterase inhibitors treatment has demonstrated regional increases,47,50 no change,48 or decreases47,48,49 in resting metabolism. The largest increase in global metabolism (26.5%) was seen after 26 weeks of rivastigmine in responders during an activation task, but not in the temporal-parietal watershed or cingulate areas.51
At the same time, texture results were mixed with a global decrease in CV52 except for the watershed areas which showed the opposite effect. This reduction in CV has corresponded to a visual pattern of smooth texture on SPECT seen in normal individuals and individuals with traumatic brain injury and post-traumatic stress disorder,52 carbon monoxide poisoning,53,54 decompression sickness,55 near-drowning,56 and cerebral palsy56 after both a single HBOT and course of HBOT. It suggests a non-specific global effect on different brain wounding/pathologies. The differential effect on CV and less robust metabolism increases in the watershed regions implies that the patient’s symptomatic improvement may be primarily due to HBOT effects on the rest of the brain. Regardless, HBOT in this patient may be the first drug to not only halt, but temporarily reverse disease progression in AD.
In conclusion, a 9-week treatment of low-pressure HBOT (40 sessions) in a patient with AD caused a significant increase in global metabolism on 18FDG PET imaging with concomitant symptomatic improvement. Mild symptomatic regression was treated with intermittent HBOT, normobaric oxygen, and medications to stabilize symptoms, suggesting the possibility of long-term HBOT treatment of AD with pharmacotherapy.
Additional files
Additional Video 1: Movie of morphed pre- to post-hyperbaric oxygen therapy 18fluorodeoxyglucose positron emission tomography single transverse image.
Additional Video 2: Movie of whole brain pre-(left) and post-hyperbaric oxygen therapy (right) 18fluorodeoxyglucose positron emission to mography transverse images (caudal to cephalad).
Additional Video 3: Movie of pre-(left) and post-hyperbaric oxygen therapy selected 18fluorodeoxyglucose positron emission tomography transverse images (caudal to cephalad) through temporal-parietal watershed regions of interest.
Additional Video 4: Movie of fused pre- and post-hyperbaric oxygen therapy (left) to post-hyperbaric oxygen therapy (right) 18fluorodeoxyglucose positron emission tomography coronal slices (anterior to posterior) through the cingulate cortices.
Additional Video 5: Movie of pre-(left) and post-hyperbaric oxygen therapy (right) 18fluorodeoxyglucose positron emission tomography cingulate cortices sagittal images (right to left).
Additional Video 6: Movie of three-dimensional surface 18fluorodeoxyglucose positron emission tomography reconstructed images pre-(left) and post-hyperbaric oxygen therapy (right).
Additional Table 1: 18Fluorodeoxyglucose positron emission tomography transverse slice cortical ribbon and posterior temporal-parietal watershed regions of interest (caudal to cephalad) pre/post hyperbaric oxygen therapy.
Additional Table 2: 18Fluorodeoxyglucose positron emission tomography coronal slice bilateral cingulate cortices regions of interest (anterior to posterior) pre/post hyperbaric oxygen therapy.
Additional Table 3: 18Fluorodeoxyglucose positron emission tomography sagittal slice bilateral cingulate cortex regions of interest (right to left) pre/post hyperbaric oxygen therapy.
Additional Table 4: Coefficient of variation in 18fluorodeoxyglucose positron emission tomography transverse slice cortical ribbon and temporal-parietal watershed regions of interest (right to left) pre/post hyperbaric oxygen therapy.
Additional Table 5: Coefficient of variation in 18fluorodeoxyglucose positron emission tomography coronal slice cingulate cortices (anterior to posterior) pre/post hyperbaric oxygen therapy.
Additional Table 6: Post-40 hyperbaric oxygen therapy (after August 2016) clinic course with Folstein Mini-Mental Status Scores.
Acknowledgements
We would like to thank Wilson H. Willie, ARRT (N) (R), for expert acquisition and processing of positron emission tomography images.
REFERENCES
1. Alzheimer's Disease International. Dementia Statistics. The Global Voice on Dementia [last accessed 2018-03-04] https://www.alz.co.uk/research/statistics.
2. Centers for Disease Control and Prevention. National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP). Alzheimer's Disease [last accessed 2018-12-19] https://www.cdc.gov/chronicdisease/resources/publications/aag/alzheimers.htm.
3. World Health Organization. Dementia [last accessed 2018-12-19] http://www.who.int/mediacentre/factsheets/fs362/en/.
View full references list
Conflicts of interestPGH is co-owner of a company that does consulting and renders expert opinions in hyperbaric medicine. EFF is vice-president of the International Hyperbaric Medical Foundation (IHMF), a non-profit corporation that promotes education, research, and teaching in hyperbaric medicine. He derives no income from the IHMF. He also owns a holding company for a mobile hyperbaric clinic named MoPlatte Hyperbarics, LLC.
Financial supportNone.
Declaration of patient consentThe author certifies that he did obtain patient consent form. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that her name and initials will not be published and due efforts will be made to conceal her identity, but anonymity cannot be guaranteed.
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Data sharing statementIndividual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices). Study protocol and informed consent form will be available immediately following publication, without end date. Results will be disseminated through presentations at scientific meetings and/or by publication in a peer-reviewed journal. Anonymized trial data will be available indefinitely at www.figshare.com.
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Keywords:
Alzheimer's dementia; hyperbaric oxygen; textural analysis; positron emission tomography; imaging pharmacokinetics; pressure pharmacodynamics